![]() The presence of multiple versions of DNA repair enzymes in a single organism is usually thought to reflect redundancy in activities that are essential for cellular viability. We have identified and characterised two apurinic/apyrimidinic (AP) endonuclease paralogues in the human pathogen Neisseria meningitidis. ![]() Oxidative stress is also used by phagocytes to attack bacterial pathogens in defence of the host. Oxidative stress is a principal cause of DNA damage, and mechanisms to repair this damage are among the most highly conserved of biological processes. ![]() Tel.: +44 2 E-mail: Division of Molecular Biosciences, Faculty of Natural Sciences, Centre for Structural Biology, Imperial College London, London SW7 2AZ, UK. *Corresponding authors: Department of Infectious Diseases, Faculty of Medicine, Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK.
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